Abstract

TRANSDERMAL DRUG DELIVERY: REVOLUTIONIZING THE WAY WE DELIVER MEDICATION AND ENHANCE THERAPEUTIC OUTCOMES

*Krutadnya P. Salve, Akabar Shaikh, *Yash Kishor Pendharkar, Sohel R. Patel, Anjali Dipak Thote and Dr. D. K. Vir

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Abstract

A Transdermal Drug Delivery System (TDDS) is a controlled method of administering drugs through the skin at a predetermined rate, offering benefits such as extended therapeutic effects, reduced side effects, and improved bioavailability. The stratum corneum, the skin's outermost layer, regulates drug penetration via appendageal, transcellular, and intercellular pathways. TDDS comprises essential components like a polymer matrix, drug reservoir, penetration enhancers, adhesives, and a protective backing layer. Transdermal patches are categorized into reservoir, matrix, and micro-reservoir systems, each designed to facilitate drug absorption into the systemic circulation through the skin. Standardized evaluation of TDDS focuses on factors such as adhesion properties, in vitro drug release, permeation studies, and stability profiles. Recent advancements have enhanced the efficiency and scope of TDDS, addressing challenges like low drug permeability and skin irritation. This review aims to comprehensively explore the progress, challenges, and expanding ‘ applications of TDDS, particularly through transdermal patches, highlighting their potential for innovative therapeutic solutions.

Keywords: Transdermal Drug Delivery System, Penetration Enhancer, Matrix System, Reservoir System.