Abstract

ANTI-GLYCEMIC AND ANTIOXIDANT ACTIVITY OF SYZYGIUM CUMINI L PLANT SKEEL PROTEIN

Dinesha Ramadas, Sujan Surya D., Viritha S., Sonu M. and Vedamurthy Joshi*

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Abstract

The skeel proteins extracted from the Syzygium cumini L. plant were investigated for their antidiabetic and antimicrobial properties through an in vitro study. Standardized methods of analysis showed a prominent presence of proteins in the plant extract. The antioxidant capacity of the crude proteins was studied using a total antioxidant model, confirming their efficacy in neutralizing free radicals. To evaluate its antiglycemic properties, the extract was tested on assays targeting the inhibition of alpha-amylase and alpha-glucosidase enzymes that are a critical part of managing the postprandial blood glucose levels. It was further evaluated by carrying out glucose uptake studies using yeast cells, hence showing that it has potential to control glucose metabolism. Significant antioxidant and antiglycemic activities of the protein-rich extract were emphasized. Hence, these findings reveal that the pharmacological properties are mainly attributed to its content of protein. Oxidative stress is associated with chronic conditions; however, this property of antioxidant activity signifies an improvement in oxidative stress that combats this phenomenon.Further, its antiglycemic effects portray that the extract could act as an agent in diabetes treatment management. This study highlights the potential of Syzygium cumini L. proteins as bioactive compounds with great promise in health and medicine, especially for conditions requiring antioxidant and glycemic control. Further research could open up avenues to understand better the mechanisms of these proteins and possibly explore their applications in drug development.

Keywords: Syzygium cumini L, Proteins, Glycemic, antioxidant.