Abstract

A REVIEW ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM (GRDDS)

K. Divya Laxmi*, G. Sowmya Sree, H. Kapileshwer, J. Devi and J. Sandhyaja

Abstract

A Controlled release dosage forms have been extensively used to improve therapy with several important drugs. However, the development processes are faced with several physiological difficulties such as the inability to restrain and localize the system within the desired region of the gastrointestinal tract and the highly variable nature of the gastric emptying process. This variability may lead to unpredictable bioavailability and times to achieve peak plasma levels. The purpose of writing this review on gastroretentive drug delivery systems was to compile the recent literature with special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. In order to understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling gastric retention. Gastroretentive dosage forms release the drug in a controlled manner to their specific site of action. There are several ways to accomplish this, including: Floating systems, Mucoadhesive systems, Magnetic systems, Expandable systems. GRDDS can enhance regulated administration of medication with an absorption window by releasing the medication for a longer period of time prior to it reaching the absorption site. Prolonging a drug's residence duration in the stomach is the aim of a gastro-retentive drug delivery system (GRDDS).

Keywords: Gastroretantive drug delivery system, Bio/Mucoadhesive System, Expanding System Gastrointestinal tract, high density system.