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Abstract

A SIMPLE SPECTROPHOTOMETRIC ASSAY OF PRAMIPEXOLE DI HYDROCHLORIDE IN BUILK AND PHARMACEUTICAL FORMULATIONS

M. Purushotham Reddy* and K. Prabhavthi

Abstract

A simple, sensitive, rapid and accurate colorimetric method has been developed for the estimation of pramipexole dihydrochloride in bulk and pharmaceutical dosage forms. The proposed method was based on the formation of chloroform extractable complex of pramipexole dihydrochloride with bromo cresol green. The absorbance of the extractable ion pair complex is measured at the wavelength of maximum absorbance 425 nm against the reagent blank. The results obtained with the proposed method are in good agreement with labeled amounts, when marketed pharmaceutical preparations are analyzed. Results obtained are statistically validated and found to be reproducible.

Keywords: Spectrophotometry, bromo cresol green (BCG), pramipexole dihydrochloride, Pharmaceutical and Formulation.


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