Abstract

DESIGN AND CHARACTERIZATION OF IN-SITU NASAL NANOEMULSION GEL CONTAINING METOCLOPRAMIDE

Shripathy D., Dhanush G. Shettigar*, Deeksha, Dhanush, Gowtham Naik A. and A. R. Shabaraya

Abstract

A nasal in-situ nano-emulsion gel formulation was developed using metoclopramide, primarily 7 nano emulsions were prepared with varying ratios of the tween 20 and alcohol mixture, here the oleic acid is the oil phase, and the distilled water is aqueous phase, these preparations are subjected to the high speed homogenization using a hand held homogenizer. The obtained nano-emulsion is transformed into an in-situ gel using respective thermo-responsive and mucoadhesive polymers using the cold fusion method. Pre-formulation studies of metoclopramide and evaluation of the formulation were also conducted. In the pre-formulation studies solubility, melting point, absorbance maxima and compatibility study of the drug and excipients is conducted and various evaluation parameters such as pH, viscosity, drug content, drug release study and gelling temperature were studied. FTIR study on the mixture of polymers revealed that there was no interaction between drugs and excipients. All the formulations showed drug content ranged between 65% to 72% and cumulative drug release was ranged between 71.2 to 79.3 %. Among the five formulations F4 was selected as the most suitable candidate because it showed optimum gelation temperature and had an ideal pH and viscosity and showed an enhanced cumulative drug release.

Keywords: In-situ, Metoclopramide, mucoadhesive, nano-emulsion, thermo-responsive.