Abstract

A REVIEW ON METHOD DEVELOPMENT AND VALIDATION OF SELECTED ANTI CANCER DRUGS ZANUBRUTINIB, ERDAFITINIB BY DIFFERENT ANALYTICAL TECHNIQUES

Santhosh Illendula*, Suthakaran Raj, Ananthula Srujana, Thummanapelly Ananthalaxmi, Pippalla Poojitha, Nenavath Meghanath, Bottu Deepthi and Rakthanala Rakesh

Abstract

Pharmaceutical analysis plays a very prominent role in quality assurance as well as quality control of bulk drugs and pharmaceutical formulation. Rapid increase in pharmaceutical industries and production of drug in various parts of the world has brought a rise in demand for new analytical techniques in the pharmaceutical industries. As a consequence, analytical method development has become the basic activity of analysis. Zanubrutinib is a kinase inhibitor used to treat mantle cell lymphoma, a type of B-cell non-Hodgkin lymphoma, in adults who previously received therapy. It effectively relieve symptoms like diarrhoea, constipation, nausea, muscle spasms. Erdafitinib is a fibroblast growth factor receptor tyrosine kinase inhibitor used to treat locally advanced or metastatic urothelial carcinoma. It effectively relives symptoms like nausea, diarrhoea, vomiting, abdominal pain, constipation.

Keywords: Pharmaceutical analysis, Zanubrutinib, Erdafitinib, analytical method development.