Abstract

EVALUATION AND DRUG STABILITY STUDIES SOME LEVOCETIRIZINE TABLETS BRANDS AVAILABLE IN SANA’A MARKET YEMEN

Abdalwali Ahmed Saif, Maged Alwan Noman, Mahmoud Mahyoob Alburyhi*and Tawfeek A. A. Yahya

Abstract

Levocetirizine hydrochloride (LCZ) is an orally administered drug used as anti-histaminic with almost no sedation. The analysis done can conveniently give a general survey of different brands of levocetirizine hydrochloride tablets where the difference in parameters tested can relate to difference in the bioavailability of drugs. Quality of tablets should fulfill certain specifications. The aim, to analysis and evaluate various pharmaceutical parameter, such as thickness, diameter, hardness, weight variation, disintegration, and dissolution, of different brands of Levocetirizine hydrochloride tablets available in the local market. According to the BP the result show that all brand pass weight variation. In diameter test all brand tablets were pass except Lazine. Thickness of all brand tablets were pass except Levar, Scohist, Levozin and Vapi mast. Hardness of all brand tablets were pass except Lazine, Scohist, Cetrizal and Vapi mast. Friability of all brand uncoated tablets were pass. Disintegration of all brand tablets were pass according to the BP. It was concluded that there are all brands tablets it evaluated according to (USP) and (BP) specifications by use different parameters mainly in dissolution test Scohist has the best result followed by Levozin > L-cetgen > Lecet > Xyex > Lazine > Vapi mast > Xaltec > Cetrizal > Utilev > Levar. Assay test results for all the brands doses not reached satisfactory limit expect, Lazine, Scohist and Xyex brands., which reached more than 90% of the drug.

Keywords: Levocetirizine hydrochloride, Tablets, Anti-histaminic, Quality control.