Abstract

HEAT STABLE COMPOUNDS IN AJWAIN (TRACHYSPERMUM AMMI) SALINE EXTRACT INHIBIT PROTEASE AND PREVENT GROWTH OF STAPHYLOCOCCUS AUREUS: AN IN VITRO STUDY

Kumar R, Bhattacharyya S*, Sarfraz A, Ansari MAA, Nitesh Jaiswal, Prasad R, Roy H, Ahmed S, Shristi

Abstract

Staphylococcus aureus is a smart bacterium causing a wide range of infections in man. It is often found to be refractory to most antibiotics. This necessitates the discovery of new natural and low-cost compounds which can inhibit growth of this pathogen, and at the same time be harmless to host cells. Our experiments showed that the saline extract of Trachyspermum ammi (ajwain) inhibits growth of S. aureus at concentration of 8 gm/100 ml and inhibits protease of the same bacterium at concentration of 4 gm/100 ml. This study can show the path of synthesizing new, low cost, active pharmaceutical compounds that could kill this pathogen.

Keywords: Ajwain, extract, virulence.