Abstract

IMPACT OF DIETARY SUPPLEMENT ON DRUG INTERACTION: A COMPREHENSIVE REVIEW

*Gayatri Prashant Gadge and Dr. Neha N. Rajpurohit

Abstract

Food-drug interactions (FDIs) represent a significant area of concern in both clinical pharmacology and patient care, influencing the efficacy, safety, and overall therapeutic outcomes of medications. These interactions occur when food components alter the pharmacokinetics or pharmacodynamics of drugs, potentially leading to adverse effects or therapeutic failure. This comprehensive review aims to explore the underlying mechanisms of FDIs, focusing on their effects on drug absorption, metabolism, distribution, and excretion, as well as their impact on receptor binding and therapeutic responses. The review also examines the factors influencing FDIs, such as patient characteristics, food composition, drug properties, and the timing of administration. It provides an in-depth analysis of the clinical implications of FDIs, with a special emphasis on the management strategies that healthcare providers can adopt to minimize risk. Specific examples of clinically relevant FDIs across various drug classes, including antibiotics, anticoagulants, and antidiabetic agents, are discussed. The review concludes by highlighting emerging research on FDIs, such as the role of gut microbiota and pharmacogenomics, and the importance of personalized medicine in mitigating these interactions. Ultimately, this paper underscores the need for heightened awareness of FDIs in clinical practice to optimize patient outcomes and ensure safe drug use.

Keywords: The review also examines the factors influencing FDIs, such as patient characteristics, food composition, drug properties, and the timing of administration.