Abstract

ANTI-INFAMMATORY EFFECT OF POLYGONUM AVICULARE L. ETHANOLIC LEAF EXTRACT IN RODENT MODES OF ACUTE AND CHRONIC INFLAMMATION: INVOMENT OF POSSIBLE MECHANISMS

Avinash Joriya*, Jitendra Kumar and Anand Singh

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Abstract

Ethanolic extracts from the leaves of Polygonum aviculare L. were assessed at doses of 500 mg/kg for anti-inflammatory effects using both acute and chronic inflammatory models. It was found that the doses possessed inhibitory effects on the acute phase of inflammation as seen in carrageennan-induced paw edema. The anti-inflammatory activity elicited by plant ethanolic leaves extracts may be due to the influence of the active constituents such as beta-sitosterol and stigmasterol. A possible mechanism may also be due to the inhibition of prostaglandin synthesis which is also evidenced by the delay in the formation of wet faeces. Further study is required to postulate the exact molecular mechanism involved in this process of inhibition of inflammation by leaves extract.

Keywords: Polygonum aviculare L, anti-inflammatory, paw edema.