Abstract

PHARMACOGNOSTICAL AND PHARMACEUTICAL ANALYSIS OF KATUKI VATI – AN AYURVEDIC FORMULATION FOR NAFLD

Manisha Chaudhary*, Mandip Goyal, Charmi Mehta and Harisha C. R.

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Abstract

Background: Katuki (Pichrorhiza kurro Royle) is a commonly used herbal medicine for liver disease management, yet no studies have been conducted specifically on Katuki Vati for the treatment of nonalcoholic fatty liver disease (NAFLD) associated with obesity. Therefore, to ensure the quality of this herbal formulation, pharmacognostical and pharmaceutical analyses were performed. Methods: Katuki Vati was subjected to microscopic evaluation for pharmacognostical identification and various physiochemical tests, including loss on drying, water and acid-insoluble extracts, hardness of the Vati, pH value, and thin layer chromatography (TLC). Results: The pharmacognostical study revealed characteristic features of the ingredients used in Katuki Vati. The physiochemical analysis showed the following results: loss on drying 94.90% w/w, acid value 35.6, water-insoluble extract 21.6%, acid-insoluble extract 19.2%, Vati hardness 2.5, and pH value 6.5. TLC analysis identified four spots at 254 nm and two spots at 366 nm. Conclusions: The pharmacognostical and physicochemical studies of Katuki Vati conform to standard parameters, providing a foundation for further research on the therapeutic efficacy of this Vati formulation.

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