Abstract

PHARMACOGNOSTICAL AND PHARMACEUTICAL ANALYSIS OF GUDUCHYADI GHRITA-AN AYURVEDIC HERBAL FORMULATION FOR MILD NEUROCOGNITIVE DISORDER

Karuna Basnet*, Mandip Goyal, Charmi Mheta and Harisha C. R.

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Abstract

Background: Mild neurocognitive disorder is a transitional phase between normal cognitive aging and dementia, marked by modest decline in cognitive functions. This underscores the critical need for early identification and effective management strategies aimed at secondary prevention. So, the polyherbal formulation Guduchyadi Ghrita was used for the clinical trial for the management of mild neurocognitive disorder. Therefore, for the assurance of quality of herbal compounds pharmacognostical and pharmaceutical analysis has been done. Methods: Guduchyadi Ghrita was subjected to pharmacognostical, and physiochemical analysis like loss on drying, acid insoluble extract, specific gravity, saponification, iodine value and thin layer chromatography (TLC). Results: Pharmacognostical study showed the presence of certain identifying characters of the ingredients of Guduchyadi Ghrita. In pharmaceutical study, preliminary physiochemical analysis showed loss on drying 0.39% w/w, specific gravity 0.917 w/w, acid value 7.119 w/w, saponification 226 w/w, iodine value 40.665 w/w and TLC showed 2 spots in 254 nm and 2 spots in 366 nm. Conclusions: The Pharmacognostical and physicochemical study of Guduchyadi Ghrita follows the standard parameters. This study can be helpful for further research regarding establishment of therapeutic efficacy of Ghrita formulations.

Keywords: Guduchyadi Ghrita, Mild neurocognitive disorder, Pharmacognostical, Pharmaceutical analysis.