Abstract

FORMULATION AND EVALUTION OF ORO-DISPERSIBLE TABLET OF AZELASTINE BY QBD

Himani Rawal* and Sachin K. Jain

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Abstract

The main objective of this work is to formulate and evaluate orodispersible tablet of Azelastine by QBD. The preformulation parameters like solubility, partition coefficient etc give good results and same as that given in the literature. The oro-dispersible tablet of azelastine was prepared with 23 factorial design. The evaluation parameters were studied like pre-compression parameters and post compression parameters. The precompression parameters like angle of repose, hardness, bulk density, tapped density was studied with good results. The post compression parameters like hardness, friability etc. was studied with good results. There were eight formulation batches prepared out of which F-3 batch showed better results as compared to other batches. The in-vitro drug release of F-3 batch was found to be 98.2 %. All the parameters were successfully evaluated. Materials and Methods: Azelastine was purchased from the Schon Pharmaceuticals, Indore. A Shimadzu- 1700 UV-Visible spectrophotometer with 1 cm matched silica cells were used for spectrophotometric analysis. Results and Discussion: The preformulation studies were successfully done. The Infrared spectrum of the drug showed major peaks at wave number characteristic of the Azelastine as compared to standard graph shown in Indian Pharmacopoeia. Solubility studies of drug in different solvent systems were performed. The oro-dispersible tablet of azelastine was prepared with 23 factorial design. There were eight formulation batches prepared out of which F-3 batch showed better results as compared to other batches. The in-vitro drug release of F-3 batch was found to be 98.2 %. All the parameters were successfully evaluated.

Keywords: Azelastine, Oro-dispersible tablet, Quality by design.