Abstract

PHARMACOLOGICAL EFFECT OF FICUS BENGHLENSIS LEAF EXTRACT ON SERUM URATE LEVELS AND VARIUS PARAMETER IN OXONATE INDUCED HYPERURICEMIC ANIMALS.

Rajendra Patil*, Sugandha Chaudhari, Mukesh Chavan, Vikram Bafna, Neethu. R., Geeta Basaiya

Abstract

Background: Ficus Benghalensis (Moraceae) Plant Species are widely available in Asian regions and used extensively in the field of Variety of disease Conditions. It includes Hypoglycaemia Activity, Anthelmintic, Anti-Inflammatory, Anti-Diabetic and mainly Anti- Oxidants Activity due to its important chemical Constituents in its leaf like Flavonoids. Materials and methods: Leaves of Ficus Benghalensis was extracted by Soxhlate Extraction Procedure and tested for its Anti-hyperuricemic activity on Wister Rats of either Sex. Results: Thirty six either sex albino rats were divided randomly into six groups. There were three group doses variations of Ficus Benghalensis extract that were 200 mg/kg bw, 300 mg/kg bw and 500 mg/kg bw. Intraperitoneal administration of Potassium oxonate (280 mg/kg bw) one hour before final test drug administration of test drugs in animals on 7th day uric acid level in plasma and urine also Total Protein content, Glutathione, Creatinine, Malonaldehyde , ESR various parameter was measured in rats after hours. The results showed that all extracts could reduce uric acid level of rats. The decreasing potency of uric acid level and various parameter in blood was observed at 300 mg/kg and 500 mg/kg dose. This results indicated that Ficus Benghalensis leaves extract may be effective for the prevention and the treatment of hyperuricemia.

Keywords: Ficus Benghalensis, Potassium oxonate, uric acid level, hyperuricemia.