Abstract

DUAL RELEASE TABLETS: A NOVEL APPROACH TO OPTIMIZED DRUG RELEASE

Nishita Nagpure*, Dr. D. R. Chaple, Dr. R. H. Kasliwal, Dr. Yogesh Gholse, Srushti Zade and Rupesh Kumar

Abstract

The Dual release tablet marks a turning point in the development of extended release tablets with a variety of features to produce an efficient drug delivery. Dual release tablets may be the greatest solution for avoiding chemical or physical incompatibilities between Active Pharmaceutical Ingredients (APIs) while also making it easier to produce medications with diverse drug release qualities. Bilayer tablets are appropriate for the sequential discharge of two medications, as well as the sustained release of a tablet with one layer for immediate discharge as a loading dose and the second layer for maintenance dose. The ongoing development of practical technology in bilayer tablets addresses the disadvantages of single-layered tablets. Today, combination therapy is employed in both developed and developing countries to treat Analgesic, anti-diabetic, and antihypertensive medications are only a few of the numerous illnesses that can be loaded using the sequential release of two drugs paired with the sustained discharge of a tablet with one layer for immediate release. Diabetes mellitus and hypertension are two disorders that require longterm care. A bilayer tablet combines compressibility with consolidation. The major goal of sustained-release bilayer tablets is to improve oral therapeutic efficacy while maintaining ideal control over medication plasma levels. The pills' bioavailability is also intended to increase patient adherence. This paper provides an overview of the manufacturing problems of bilayer tablets, including the numerous tablet presses used, the standard and current good manufacturing practice protocol for their mass production, the various dual release tableting procedures and techniques, pre and post compression evaluation, and software.

Keywords: Bilayer tablets, sustain release, fast release, Maintenance dose, Loading dose, Consolidation, Compression, current good manufacturing practice requirements, pre and post evaluation, software, techniques.