Abstract

DISPERSIBLE AND ORODISPERSIBLE TABLETS DELIVERY SYSTEMS FOR ANTIBACTERIALS DEVELOPMENT

Mahmoud Mahyoob Alburyhi*, Maged Alwan Noman, Abdalwali Ahmed Saif and Abdu Faisal Alemad

Abstract

The most common and preferable route of drug administration is through the oral route. Novel oral drug delivery systems aim to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for ease of administration and to achieve better patient compliance. Orodispersible tablets (ODTs) are among these systems, the concept of Orodispersible tablets is to disperse the tablets within seconds in the mouth in the presence of saliva with no need for water, and without any difficulty of swallowing, due to the presence of superdisintegrants in their formulation. Solid dose forms known as Orodispersible tablets (ODTs) dissolve in the mouth in less than1min, allowing for water less swallowing. Orodispersible tablets results in rapid dissolving and, thus, a rapid start of action. Pediatrics, the elderly, psychotic, dysphagic, bedridden, comatose, young patients with under developed neurological and muscular systems, patients with hand tremors, and patients who travel frequentlyare among the particular populations for which Orodispersible tablets ODTs are an appropriate dosage form. It offers reduced packing size, precise dosing, superior stability, and convenience of manufacture. Since water is not needed during transportation, self-administration is feasible. Orodispersible tablets ODTs are a cost- effective way to distribute medications. When a medicine is absorbed from the buccal cavity, Orodispersible tablets ODTs are a crucial drug delivery method. For the creation of Orodispersible tablets ODTs, a variety of scientific methods have been used, including as molding, direct compression, spray drying, sublimation, and freeze drying. Orodispersible tablets ODTs are becoming more readily accessible as over-the-counter medications for the treatment of a wide range of illnesses. The objectives of this article are reviewing dispersible tablets and Orodispersible tablets ODTs benefits, drawbacks, formulation difficulties, manufacturing processes, patented technologies, commercial formulations, and evaluation testing.

Keywords: Orodispersible tablets, Dispersible tablets, Superdisintegrants, Evaluation methods, Development.