Abstract

REVIEW ON TRANSDERMAL PATCH

Priya Chidrewar*, Monika Pate, Siddhi Ambilwade, Alisha Mulla

Abstract

The transdermal drug delivery route has significant advantages over the conventional oral route. It can provide more patient compliance, especially in patients with swallowing problems, more stable serum drug levels, pain-free drug administration, avoiding hepatic first pass metabolism and drug degradation in the GIT, food-drug interaction and reducing side effects. TDDS is suitable for long term administration, especially for insulin and analgesic drugs. However, the low skin permeability which limits drug penetration and inconsequence affects drug bioavailability, represents the most challenging mission for delivering. Nanostructured lipid carrier (NLC) is the second generation of lipid nanoparticles, which was created to overcome the drawbacks of the solid-lipid nanoparticles (SLNs), such as the low drug loading capacity, gelatin and reduced stability. Transdermal drug administration is a successful method of increasing drug bioavailability. The transdermal route is a potential alternate route with a variety of characteristics that might be advantageous. The location and adherence of the patch at the site of action, the lipid solubility of the drug molecule and the structural contents of the lipids and proteins in the epidermis are modifying variables that influence transdermal absorption as well as drug bioavailability. The lipid nanoparticle-based method by transdermal delivery is regarded as a safe choice due to improved patient compliance and controlled release relative to other delivery systems. The NLCs consist of combination of liquid and solid lipids, leading to a lower melting point for solid lipids while remaining solid at body and room temperature. Lipid nanoparticles have a variety of features that make them suitable for topical usage in cosmetics and medicinal formulations. Because of extensive positive benefits such as skin hydration, skin occlusion and skin targeting, NLCs have a significant potential in the pharmaceutical market. Skin hydration is important for API topical distribution because it hydrates the skin, which causes the pores to open. Nanoparticles are colloidal particles that range in size from 10 to 1000nm. Surface modification of NLCs is also possible. Nanotechnology has revolutionized the field of drug delivery systems, offering improved efficacy, stability, and bioavailability of therapeutic agents. This review highlights the application of nanotechnology in the treatment of hypertension, a major risk factor for cardiovascular disease.

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