Abstract

NANOSTRUCTURED LIPID CARRIERS: A REVOLUTIONARY PATH FOR TARGETED DRUG DELIVERY AND DISEASE MANAGEMENT

*Ms. Shravani Girigosavi, Dr. Yogesh Gurav, Dr. Amit Kasabe, Ms. Gauri Kashid and Mr. Parth Shinde

Abstract

Nanostructured lipid carriers (NLCs) are gaining significant attention in both cosmetics and pharmaceuticals due to their versatile properties. In cosmetics, NLCs are utilized to enhance the delivery of active ingredients, such as vitamins and antioxidants, ensuring deeper skin penetration and improved effectiveness. They also offer controlled release, protecting sensitive compounds from environmental degradation caused by UV exposure and oxidation. In pharmaceuticals, NLCs provide a promising solution for the delivery of poorly soluble drugs. They improve bioavailability, protect sensitive molecules, and allow for targeted delivery to specific sites, minimizing side effects. NLCs are particularly useful for delivering a range of therapeutic agents, including anticancer drugs and antibiotics, enabling more efficient treatment options. A review related to NLC technology highlights ongoing innovations in drug delivery systems and patents focus on developing novel formulations, enhancing drug encapsulation techniques, and optimizing release profiles. This reflects the growing interest in NLCs as a means to improve the performance and stability of both pharmaceutical and cosmetic products. Despite their potential, several challenges remain. Issues like large-scale production difficulties, formulation consistency, regulatory approval hurdles, and concerns about skin irritation or toxicity need to be addressed. Furthermore, the long-term stability of drugs encapsulated within NLCs continues to be a challenge. Looking ahead, future developments in NLC technology are focused on improving targeting mechanisms, enhancing stability, and integrating NLCs with advanced technologies such as nanogels. These advancements could further optimize drug delivery and expand NLC applications in personalized medicine and advanced cosmetic treatments.

Keywords: Nanotechnology, Nanostructured lipid carriers (NLCs), Targeted drug delivery, Lipid nanoparticles, pharmaceutical delivery.