Abstract

FORMULATION, OPTIMIZATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC PUMP TABLETS FOR ORAL DELIVERY OF VERAPAMIL HYDROCHLORIDE

J. Adlin Jino Nesalin*, Megharaj N. H., Debasish Dey, Rakshitha, Sindhu A. and Vaishnavi D.

Abstract

The present study was undertaken with the aim to formulate, evaluate and optimize Controlled Porosity Osmotic Pump (CPOP) tablets of Verapamil hydrochloride. The core tablets were formulated by direct compression method and coated using semi permeable membrane which contains pore forming agents compared to drilling method, this method proves to be cost effective and can easily formulated and coated in laboratory itself. The influence of the concentration of Sodium Chloride (NaCl) and Microcrystalline cellulose (MCC) [Independent variables] on % drug release and hardness (Dependent variable) respectively was demonstrated by using Central composite method in Design expert software (DOE). The drug-polymer incompatibility was ruled out by FTIR studies. Evaluation studies like in vitro drug release, hardness, for each formulation were performed and the data obtained were used in DOE to get optimized formula and the optimized tablets were formulated, evaluated to get desired output. From this study we can conclude that, DOE software has made our work less fatigue with lesser number of runs and optimized formulation gave pre-determined response. The study over 6 hours has confirmed that our formulation exhibits controlled release properties.

Keywords: Verapamil hydrochloride, controlled porosity osmotic pump (CPOP) tablets, dependent variables, independent variables, DOE (Design expert software).