Abstract

DEVELOPMENT AND EVALUATION OF ANTIHYPERTENSIVE TRANSDERMAL PATCH OF VALSARTAN

Reshma R. Adhal* and Dr. Sachinkumar D. Gunjal

Abstract

The transdermal patch formulation was found to be efficacious, safe, stable and non-irritant to skin. IR spectra of the drug matches with standard functional group frequencies of drug. The pH of formulated transdermal patches was found to be in the range of 6.8, which lies in the normal pH range of the skin, which indicates the suitability of the formulations for application on the skin to avoid any irritation upon application. The formulation F1 (Gelatin and PVA using propylene glycol as a plasticizer) was optimized. The above formulation gave a maximum drug diffusion of 99.8 % over a period of 120 min. The Drug Content results indicated that the process employed to prepare transdermal patches formulations in this study was showed significant result of uniform drug content.

Keywords: TDDS, In Vitro Drug Release Study, Patch, PVA, plasticizer, Gelatin.