Abstract

FORMULATION AND EVALUATION OF DIPHENHYDRAMINE HCL RELEASE FROM DIFFERENT SEMI-SOLID BASES (CREAM, GEL & OINTMENT)

Kirolos Raje Fakhry, Khidir Agab Mohammed Hassan*

Abstract

Background: Topical formulations are often used for relief of itching due to insect bites, mild cases of sunburn, poison ivy or oak, and other minor skin irritations. Currently, diphenhydramine is available on the market in few topical dosage forms, containing 2% of drug and its percutaneous absorption was scantily investigated. In developing novel drug preparations for topical delivery through the skin, the choice of vehicle formulations for a given drug can greatly influence the rate and extent of drug permeation across the skin. Method: Different bases (ointment, cream and, gel) were prepared and one gram of each base was placed in the dissolution basket apparatus, which was covered with the skin of a rat to simulate the percutaneous absorption, and the amount of drug released through the rat skin in the dissolution media, was measured spectrophotometerically. Results: The different bases of diphenhydramine have shown different release rate. Conclusion: Diphenhydramine incorporated into a gel base (Carbapol base ) has shown the highest release rate.

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