Abstract

EVALUATION OF ANALGESIC ACTIVITY OF EXTRACT OF POLYALTHIA LONGIFOLIA SEEDS ON EXPERIMENTAL ANIMALS

Ashoka Shenoy M.*, Midhuna K., Alveera Ancita Dsouza, Ashel Rovita Lobo, Ayshathul Shahala S. and Shriraksha P.

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Abstract

Aim and Objective: The aim of this study was to evaluate analgesic activity of ethyl acetate extract of Polyhalthia longifolia seeds on experimental animals. Method: The analgesic activity of Polyalthia longifolia seed extract in mice was investigated by using Eddy‟s hot plate method. The mice were categorized into four groups: the control group received a vehicle solution, the standard group was administered Diclofenac sodium, and the test groups were given oral doses of Polyalthia longifolia seed extract at 200mg/kg and 400mg/kg, respectively. Analgesic activity was measured by assessing the mice basal reaction times on a hot plate maintained at 55±0.5°C. Observations were recorded at intervals of 0, 30,60, and 90 minutes after administration, with a 15-second cut off to avoid paw injury. The parameters like licking their fore or hind paws and jumping response were measured. Results: The administration of the dose (200mg/kg and 400mg/kg) of ethyl acetate extract of Polyalthia longifolia seed produces significant increase in the basal hot plate latency period (P

Keywords: Pain, Analgesic, Polyalthia longifolia, Eddy’s hot plate.