Abstract

FORMULATION AND EVALUATION OF BILAYER TABLET OF SUSTAINED RELEASE NIFEDIPINE AND IMMEDIATE RELEASE CAPTOPRIL AS ANTIHYPERTENSIVE DRUG

Puranik Aboli* and Puranik Deep

.

Abstract

The aim of present study was to prepare bi-layer tablet of Nifedipine and Captopril for the effective treatment of Hypertension. Nifedipine and Captopril were formulated as Sustained and Immediate release respectively. Wet granulation method was used for the formulation of the both layers. The sustained release layer of Nifedipine was prepared by using different grades of HPMC like HPMC K4M, HPMC K100M. The drug-excipient compatability studies confirmed that both drugs are compatible with excipients by using FT-IR and DSC. The in–vitro dissolution studies were performed by USP–II type dissolution apparatus. The release of Nifedipine from sustained release layer was found to be 99.93% in 12 hours. The release of Captopril for immediate release layer was found to be 99.38% drug release in 60 min. Stability study was carried out at 40 ± 2°C and 75 ± 5% RH up to 3 months. The release kinetics of the optimized tablets showed that it follows zero order release kinetics for sustained release and Matrix release kinetics for immediate release layer.

Keywords: Bilayer tablet, Nifedipine, Captopril, Immediate release, Sustained release, Hypertension.