Abstract

PULSATILE DRUG DELIVERY

A K Dhadwe*, C P Rathod, S M Vadvalkar, G R Shendarkar, P H Bhosale and Patil K G.

Abstract

The release of the drug as a pulse after a lag time has to be designed in such a way that a complete and rapid drug release follows the lag time. Various systems like capsular systems, osmotic systems, single and multiple-unit systems based on the use of soluble or erodible polymer coating and use of rupturable membranes have been dealt with in the article. It summarizes the latest technological developments, formulation parameters, and release profiles of these systems.In the present work Eudragit S 100 alone is used for coating. Batches were coated in different percent weight gain from 1-7 percent. These coated tablets showed increase in the lag time with increase in the coating level. The lag time increases from 2 to 8 hrs for the coating of 1-7 % respectively. This study was utilized to optimize the formulation. The present work concludes that there is a constant need for new delivery systems that can provide increased therapeutic benefits to the patients. Pulsatile drug delivery is one such system that, by delivering drug at the right time, right place, and in right amounts, holds good promises of benefit to the patients suffering from chronic problems like arthritis, asthma, hypertension, etc.

Keywords: Modified release oral tablet; Single pulsatile drug; Sustain action; Challenges; Approaches; Market status.