Abstract

TOPICAL NANO-EMULGEL FOR SKIN DISORDERS: A COMPREHENSIVE REVIEW

Sayali S. Patil* and Rutuja R Shah

Abstract

Nanoemulgel is a powerful delivery method for lipophilic medicines. The word nanoemulgel refers to an emulsion that has gelled due to the presence of a gelling agent. The attention on nanoemulgels has also increased due to their ability to achieve targeted distribution, ease of application, lack of gastrointestinal degradation or first pass metabolism, and safety. They come in o/w or w/o forms, with one immiscible liquid spread as droplets inside another. Hydrogel-based nanoemulsion systems, also known as nanoemulgels, are homogeneously distributed systems in which the hydrogel matrix enhances nanoemulsion skin penetration (10-200 nm droplets). With greater drug loading due to higher solubilizing effectiveness, better bioavailability due to superior permeability, and the capacity to modulate drug release, it is a potent alternative delivery strategy for treating a range of disorders. It has been demonstrated that nanoemulgel formulations are considerably more effective in treating inflammation caused by rheumatoid arthritis, psoriasis, fungal infections, acne, and pimples. A nanoemulgel's outstanding features, such as thermodynamic stability, permeability enhancement, and prolonged release, make it an ideal dosage form. This review focuses on the varieties, advantages, and downsides of nanoemulgels, as well as their constituents, preparation methods, and numerous characterisation investigations.

Keywords: Inflammation, Nanoemulgel, Topical application, solubility.