Abstract

CLINICAL EFFICACY AND SAFETY EVALUATION OF HIGHCONCENTRATION MONTERANC AMPOULES: A RANDOMIZED CONTROLLED TRIAL ON SKIN AGING AND REJUVENATION

Yoshida Hiroki MD*

Abstract

Skin aging, characterized by wrinkles, reduced elasticity, and pigmentation, arises from intrinsic and extrinsic factors. Bioactive compounds, including polydeoxyribonucleotide (PDRN), epidermal growth factor (EGF), glutathione, and peptides, have gained attention for their regenerative and protective properties. This randomized controlled trial evaluated the efficacy and safety of high-concentration Monteranc ampoules containing these ingredients on various skin parameters. The study enrolled 120 female participants aged 25–55 years from diverse ethnic backgrounds. Participants were divided into four groups to test PDRN, EGF, Glutathione, and Peptide ampoules over 2–4 weeks using advanced dermatological measurement tools. Results demonstrated significant improvements in pore size, pigmentation, hydration, texture, and elasticity across all groups (p < 0.05), with no adverse reactions reported. Each ampoule exhibited unique strengths: PDRN refined pores and texture, EGF enhanced brightness and reduced pigmentation, Glutathione offered antioxidative benefits, and Peptides improved hydration and elasticity. These findings affirm the potential of Monteranc ampoules as effective skincare solutions for targeted anti-aging treatments. Further studies are warranted to assess long-term outcomes and broader applicability.

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