Abstract

POTENTIAL ACTIVITIES OF QUINOXALINE DERIVATIVES – A REVIEW

Gollapalli Naga Raju*, Ramayanam Lakshmi Madhuri, Pattan Shaheena, Nadendla Ramarao

Abstract

Quinoxaline derivatives constitute an important class of heterocycles in drug discovery. They are clinically effective as antibacterial, antifungal, anti-inflammatory, anticancer, anti-tubercular and antineoplastic agents. Interestingly, it also shows hypoglycemic and antiglaucoma activity. Modification in their structure has offered a high degree of diversity that has proven useful for the development of new therapeutic agents having improved potency and lesser toxicity. Considering the extensive research on quinoxaline in the past, it was essential to review the wide spectrum of biological activity of quinoxalines. To conclude, this review will be beneficial for new drug discovery of quinoxaline moiety.

Keywords: Quinoxaline, Antibacterial, Anticancer, Anti-oxidant, Anti-inflammatory.