Abstract

AN INVITRO ANTI-MICROBIAL ACTIVITY AND DRUG DIFFUSION STUDY OF DAMARU YANTRA SHODHITA, CHAKRAMARDA BHAVITA AND GODUGDHA SHODHITA GANDHAKA

Dr. Rohini Nagendra*, Dr. Seema M. B. and Dr. Surekha S. Medikeri

Abstract

Introduction: The rising incidence of superficial fungal and bacterial infections coupled with resistance to topical agents, necessitates the development of novel dosage forms. In Ayurveda, Gandhaka and Chakramarda are known for their excellent antimicrobial properties, both internally and externally. This study aims to do Bhavana of Damaru yantra Shodhita Gandhaka using Chakramarda Swarasa and assess its antimicrobial activity and drug permeation by comparing it with Damaru yantra shodhita Gandhaka and Go-dugdha shodhita gandhaka. Materials and methods: Damaru yantra shodhita gandhaka (DYSG), fresh Chakramarda patra, Godugdha Shodhita Gandhaka (GSG), microorganisms, Franz diffusion cell, Uv- Spectrophotometry. Organoleptic, instrumental analysis and diffusion studies were conducted. Results: The differences in antimicrobial activity between Damaru Yantra Shodhita/Godugdha Shodhita Gandhaka and Chakramarda Bhavita Gandhaka (CBG) stem from the incorporation of phytoconstituents from Chakramarda Swarasa during Bhavana. Among all the 3 samples CBG showed better results in the drug diffusion study. Conclusion: CBG showed activity against different microorganisms when compared to DYSG and GSG, and highest penetration in the drug diffusion study.

Keywords: Charamarda, Damaru Yantra Shodhita Gandhaka, Anti-microbial action, Drug diffusion study.