Abstract

COMPARATIVE PHARMACEUTICO-ANALYTICAL STUDY OF VACHA GHRITA AND AVARTITA VACHA GHRITA

Dr. Chaitra D. C*, Dr. Seema M. B. and Dr. Surekha S. Medikeri

Abstract

Background and Objective: Avartana is a unique concept in Ayurveda pharmaceutics mentioned for Sneha Kalpana. It‟s a key to obtain a concentrated and more potent formulation, with repeated processing. Avartita Vacha Ghrita (AVG), is a formulation mentioned in Sushrutha Samhita, Medhayushkamiya Chikitsa. This formulation was selected and subjected to a total of 21 Avartanas. Pharmaceutico- Analytical study was performed to compare the Physicochemical changes occuring in successive AVG samples, specifically the 1st, 5th, 10th, 15th, 20th and 21st samples. Quantitative estimation of a therapeutically potent phytoconstituent, Beta Asarone, of the drug Vacha, was estimated, in the above samples. Methods: 21st Avartita Vacha Ghrita was prepared, the above samples were subjected to Physicochemical and Instrumental analysis. Results: During Pharmaceutical process, no much Organoleptic changes were observed on successive avartana, except the consistency of Kalka in the later cycles. As per Physicochemical analysis, on successive Avartana, gradual increase in Refractive index, Specific gravity, Iodine value, Acid value, a notable increase in Saponification value, a slight decrease in pH were observed. The concentration of Beta Asarone significantly increased in successive Avartana. Conclusion: The study indicates significant increas e in the solubilization of active phytoconstituents on successive Avartana

Keywords: Avartana, Avartita Vacha Ghrit a ( AVG), Physic ochemical analysis