Abstract

"INVESTIGATION OF BIOLOGICAL ACTIVITY OF COPPER (II)- CHLORPHENAMINE COMPLEX"

Veer Singh Lodhi*, Rita Bamnela, Maneesha Jain

Abstract

The Copper (II)-Chlorphenamine complex has been synthesized and studied for its physicochemical, antimicrobial, and pharmacological characteristics in both solid and solution phases. Advanced techniques such as polarographic analysis, amperometric titration, IR spectroscopy NMR spectroscopy and polarography were used to confirm the complex's stoichiometry, which was determined to be 1:1 (Copper (II): chlorphenamine). The metal-ligand interactions were investigated through polarographic methods at 25 ± 1°C and an ionic strength of μ = 1.0 (KCl). The antimicrobial activity of the complex was evaluated against various pathogenic bacteria, including Pseudomonas Mangifera, Staphylococcus aureus, Salmonella typhi, and Vibrio cholerae, along with fungi such as Trichothesium and Chrysosporium spp., using Raper's methodology. with fasting for 12 hours prior to intraperitoneal administration of the complex. Results from both in vitro and in vivo evaluations revealed that the antimicrobial and antihistamine activities of the copper (II)-chlorphenamine complex were nearly twice as effective as the pure drug.These findings suggest that the copper (II)- Chlorphenamine complex holds promise as a more potent antihistaminic agent and merits further investigation by pharmaceutical researchers.

Keywords: Chlorphenamine, Cu(II) Complex, Antihistaminic IR and NMR spectral study etc.