Abstract

ROLE OF ADHESION MOLECULE IN DIABATIC COMPLICATIONS

Aman Sharma*, Ritu Dahiya, Shivani Rajput, Kartik Mani Pathak

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia, which can lead to a range of microvascular and macrovascular complications. Adhesion molecules, a group of proteins involved in cell-cell and cell-extracellular matrix interactions, play a crucial role in the pathogenesis of diabetic complications. These molecules, including selectins, integrins, and the immunoglobulin superfamily, are upregulated in response to hyperglycemia and contribute to the inflammatory processes that underlie diabetic complications such as retinopathy, nephropathy, neuropathy, and cardiovascular disease. The activation of adhesion molecules leads to endothelial dysfunction, increased vascular permeability, and enhanced leukocyte adhesion and migration, all of which exacerbate tissue damage. Understanding the role of adhesion molecules in diabetes not only provides insight into the mechanisms driving these complications but also highlights potential therapeutic targets for preventing or mitigating the progression of diabetic complications. This abstract underscore the important Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia, which can lead to a range of microvascular and macrovascular complications. Adhesion molecules, a group of proteins involved in cell-cell and cell-extracellular matrix interactions, play a crucial role in the pathogenesis of diabetic complications. These molecules, including selectins, integrins, and the immunoglobulin superfamily, are upregulated in response to hyperglycemia and contribute to the inflammatory processes that underlie diabetic complications such as retinopathy, nephropathy, neuropathy, and cardiovascular disease.

Keywords: Adhesion molecules, Diabetes, Dysfunction, Leukocyte Adhesion, Inflammatory Pathways, Extracellular Matrix Remodeling, Microvascular and Macrovascular Disease, Oxidative Stress.