Abstract

SYNTHESIS AND DESIGN OF A NOVEL SUBSTITUTED MORPHOLINE DERIVATIVES AND EVALUATION FOR THEIR ANALGESIC ACTIVITY

Dr. P. R. Logeshkumar*, Dr. P. Vasanthkumar, S. Usman Altamash, L. Bhanuvardhan Reddy, M. Anil Kumar Reddy, Adhikeshava Reddy C., S. Zubair, S. Mohammad Khaleed, S. Shafeek Basha, D. Rohith, B. Geetha Krishna and S. Naif

Abstract

Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a moiety of great significance. It forms an important intermediate in many industrial and organic synthesis. Morpholine containing drugs are of high therapeutic value. This review discusses the synthesis of morpholines, a heterocycle that is often used in medicinal chemistry. It highlights the importance of morpholines in drug discovery and their contribution to the biological activities of bioactive molecules. This article discusses the wide range of applications of morpholine, an organic chemical compound with a six-membered ring. It covers its use in medicinal chemistry, such as in analgesics, as well as its industrial applications, such as in corrosion inhibition and as a catalyst. This review discusses the morpholine ring as a versatile synthetic building block that can be used in drug design and development. It highlights the morpholine ring's contribution to the biological activities of bioactive molecules and its role in improving their pharmacokinetic profile.

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