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World Journal of Pharmaceutical Research (WJPR) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
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Abstract

UNDERSTANDING AMA AND ITS ROLE IN CHRONIC DISEASES

Dr. Kishori Yadav* and Dr. Swapnil Ashok Mundhe

Abstract

In Ayurveda, Ama is described as a toxic byproduct of impaired digestion and metabolism, resulting from the incomplete transformation of food. It is considered a fundamental etiological factor in the pathogenesis of various chronic diseases. Ama is characterized by its heaviness, stickiness, foul smell, and ability to obstruct the channels of the body (srotorodha), leading to physiological imbalances. This article explores the concept of Ama, its genesis, properties, and its role in the manifestation of chronic diseases through doshic imbalances and accumulation in specific organs and systems. Chronic diseases such as autoimmune disorders, metabolic syndromes, gastrointestinal conditions, and cardiovascular diseases often exhibit pathophysiological patterns analogous to the concept of Ama in Ayurveda. The interaction between Ama and the tridoshas— Vata, Pitta, and Kapha—further exacerbates the pathological processes by creating an environment conducive to inflammation, impaired immunity, and metabolic dysfunction. Therapeutic approaches for managing Ama involve digestive stimulants (dipana), carminatives (pachana), detoxification therapies (shodhana), and dietary modifications to restore digestive fire (agni) and prevent Ama formation. Modern perspectives on Ama align with the growing understanding of chronic inflammation, gut dysbiosis, and toxin accumulation in contemporary medicine. This review aims to bridge traditional Ayurvedic insights with modern medical paradigms to provide an integrative understanding of Ama and its implications in chronic disease ma nagement.

Keywords: Ama, Agni, Chronic Diseases, Ayurveda, Pathogenesis, Detoxification, Inflammation, Srotorodha


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