Abstract

PROGESTERONE AND ITS DERIVATIVE AS ANTICANCER

Prof. Arati Bhetariya*, Dr. Dinesh K. Dangar, Ms. Morvi M. Raval, Ms. Krupali B. Jadav, Ms. Payal H. Chhelana, Ms. Hetvi M. Sojitra, Mr. Devang J. Ram

Abstract

Human cells grow and multiply to form new cells as the body needs them. When cells grow old or become damaged, they die, and new cells take their place.[1] Sometimes this orderly process breaks down, and abnormal or damaged cells grow and multiply when they shouldn’t. These cells may form tumors, which are the lump of tissue. It occurs when it ignore signals that normally tell cells to stop dividing or to die, trick the immune system into helping cancer cells to stay alive and grow. So, nowadays progesterone and its derivative is used in the cancer treatment (NCI). It was found that Wnt pathway have role in cell growth ad proliferation, here progesterone and its derivatives we use for anticancer activity. Progesterone binds to nuclear and membrane progesterone receptors (PRs) to regulate the expression of genes that control cell growth and apoptosis. Here progesterone derivatives which is presented are Medroxyprogesterone acetate (MPA), Megestrol acetate (MA), Cyproterone acetate (CTA), Chlormadione acetate (CA) and dydrogesterone and review on its activity as anticancer. Further study is proceeding on it, currently this work is review based.

Keywords: These cells may form tumors, which are the lump of tissue.