Abstract

A REVIEW ARTICLE ON BIOLOGICAL ACTIVITIES OF OXADIAZOLE DERIVATIVE

Jayaseelan K.*, Arunagiri M., Bhavadharani S., Deepalakshmi G., Surya V.

Abstract

Most of the currently marketed drugs consist of heterocyclic scafolds containing nitrogen and or oxygen as heteroatoms in their structures. Oxadiazoles and their derivatives with thioether functionalities represent a new and exciting class of physiologically active heterocyclic compounds. Several molecules with these moieties play a vital role in pharmaceuticals because of their diverse biological activities. Oxadiazole is considered to be resultant from furan by replacement of two methane (–CH=) groups by two pyridine type nitrogen atoms (–N=).The principle structure of the Oxadiazole ring with a pair of Pyridine-type nitrogen atoms has been confirmed to be valuable for Oxadiazole analogues for having efficacious protein interactions with a large number of enzyme proteins and receptor proteins present in the organ system of the human body through different types of interactions, like Vander Wall interactions, thereby producing a huge variety of biological activities or pharmacological properties. Due to the variety in the pharmacological activity of Oxadiazole and their derivatives and analogues, they have been termed as one of the important pharmacological aspects to study. Multiple numbers of oxadiazole related synthetic compounds possessing high potent action and therapeutic activity are being widely incorporated for treatment and management of multiple diseases and disorders, giving immeasurable progression and establishment value. Oxadiazole derivatives express a multiple number of pharmacological activities like antimicrobial, anti-inflammatory, analgesic, antifungal, antipyretic, antidepressant, anti tubercular, antico nvulsant, anticholinesterase, antihypertensive, antidiabetic, antitumor/anticancer, anti HIV, antioxidant, etc. The history of 1,3,4 Oxadiazole is also very interesting. It shows that it attracted many chemists, researchers, and scientists to explore the O xadiazole nucleus as a biologically active molecule having promising potency. This review article mainly focuses on the pharmacological profile of 1,3,4 Oxadiazole with various activities and examples (in the form of figures and structures). Expectations a re that this article will be like a path showing torch to help and serve as guidance for new innovations/ideas along the progression of research for the evolution of more active/potent and less poisonous/toxic Oxadiazole based derivatives.

Keywords: 1,3,4 Oxadiazole; Biological activities; Antimicrobial; Anti tumor; Anti inflammatory; Anti convulsant; anti oxidant; Anti oxidant.