Abstract

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF 2- AMINO-6-METHYLPYRIDINE-4-THIAZOLIDINONE HYBRIDS AS ANTI-INFLAMMATORY AGENTS

Deepak Singh Bisht*, Saurabh Saklani, Rabin Debnath, Shalini Rawat and Sneha

Abstract

Inflammation, characterized by uncontrolled cell proliferation and the ability to invade other tissues, remains a leading cause of morbidity and mortality worldwide. The multifactorial nature of inflammation involves genetic mutations, hormonal influences, and complex cellular signaling pathways. This study explores the design, synthesis, and biological evaluation of 2-amino-6-methylpyridine 4-thiazolidinone hybrid molecules as potential inhibitor of inflammation, aiming to contribute to the development of novel anti-inflammation agents. Firstly, 22 compounds were designed based on literature survey out of these compounds ten compounds were found to be most potent based on the docking studies and these ten new derivatives (DSB001-010) were synthesized and subjected to in silico, in vitro, and ADMET profiling to identify the most potent compound. Compound DSB-009 emerged as the most potent, with an IC50 value of μM, confirmed by docking studies. These compounds were further characterized using IR, NMR, and mass spectrometry.

Keywords: Inflammation, methylpyridine, biological evaluation, docking studies and thiazolidine-4-one hybrid.