Abstract

SYNTHESIS NOVEL LIGENDS DERIVED FROM SULFADRUGS AND CHROMOTROPIC ACID AND THEIR COMPLEXES WITH OXOVANADIUM (IV)

Tarek A. Fahad*, Asaad A. Ali and H. Abd-al-samad

Abstract

Three novel azo dyes ligands (L1, L2 and L3) derived from sulfanilamide, sulfamethaxazole and sulfadiazine with chromotrpic acid, were synthesized. Characterization of these dyes have been done on the basis of elemental analysis, FT-IR. The work involves a study of acid – base properties of ldyes (as ligand ) at different pH values. The ionization and protonation constants were also calculated. The complexes of L1 – L3 with Oxovanadium (IV) were studied and prepared. These complexes have been concluded after fixing the optimum conditions (The effects of time, pH and sequence of addition). The spectra of the complexes solutions have been studied for a range of concentrations which Lambert – Beer s law were obeyed. The stoichiometry of the complexes has been found to be 1:2 (metal : ligand). The overall stability constants were determined by the corresponding solutions method. The ligand were screened for their antimicrobial activity.

Keywords: Azo compounds; Sulfa Drugs, Oxovanadium (IV) complexes, Spectroscopy and Biological activity.