Abstract

SCREENING OF WOUND HEALING ACTIVITY USING MATURATION OF SILVER NANOPARTICLES EXTRACTED FROM POLYHERBAL FORMULATION IN ALLOXAN INDUCED DIABETIC RATS

Satish Kalshetty*, Amit Kumar and Mohd. Rafiq

Abstract

Nanoparticles are materials with overall dimensions in the nanoscale, ie, under 100 nm. In recent years, these materials have emerged as important players in modern medicine, with applications ranging from contrast agents in medical imaging to carriers for gene delivery into individual cells. Nanoparticles have a number of properties that distinguish them from bulk materials simply by virtue of their size, such as chemical reactivity, energy absorption, and biological mobility. The present work was aimed to detect the wound healing and maturation of silver nanoparticles (SNP) extracted from polyherbal plants (Semecarpus Anacardium, Vachellia Nilotica, and Portulaca Quadrifida). 20g of selected polyherbal contains 20mg of SNP. SEM and XRD analysis showed the size and characterization of the silver particle was less than 100nm. Thermal wound induced in diabetes animals model was used for wound healing effects of SNP. The wounds decreased in size gradually with time, closed at 2 weeks in normal mice and at 3 weeks in diabetic mice. In diabetic mice at 15 days, a significant difference in (P

Keywords: Wound healing, Polyherbal, Diabetes mellitus, Silver nano particles.