Abstract

EFFICIENCY OF SACCHAROMYCES BOULARDII ON BLASTOCYSTIS HOMINIS IN LABORATORY MICE

Israa Mohammad Abd AL-Khaliq* and Dr. Sabaa Taher Mohammed.

Abstract

The effectiveness of Saccharomyces boulardii yeast as vital probiotics on this parasite was studied in the laboratory mice and compared with metronidazole which used usually in the treatment of intestinal parasites ,included Blastocystis hominis parasite, it was noticed a gradually decreased in the numbers of parasite in stool of mice since the first day of treatment parasite disappeared in the day (12th ) from treatment with Saccharomyces yeast, and disappeared in day (13th ) from treatment with metronidazole, and when efficacy of treatment counted for both of S. boulardii and metronidazole ,founded that this yeast have a higher efficacy for treatment (87.45%) , while mitronidazole efficacy was (81.36%). The microscopic examination to histological sections of the infected mice in cecum and colon regions showed the ability of the parasite to make histological changes included intense inflammatory-cell infiltration, and mucosal damage. The yeast of Saccharomyces boulardii showed higher ability in the healing and recovering damaged tissues compared with metronidazole which showed less efficacy in healing and recovering damaged tissue.

Keywords: Blastocystis hominis ,Saccharomyces boulardii , probiotic, mitronidazole.