Abstract

CURRENT TRENDS AND ADVANCES IN MUCOADHESIVE MICROSPHERES: A NOVEL APPROACH OF CONTROLLED RELEASE DRUG DELIVERY

Shivani Subhash Pangarekar*, Tejeswini Vikramsinh Deshmukh and Chaitanya

Abstract

In the recent years, there has been a lot of interest in designing drug delivery systems that use mucoadhesive microspheres to build up unique controlled release drug delivery. Current drug delivery system having the novel approach is to concentrate the treatment to targeted site while lowering the drug concentration. Carrier technology provides an intelligent method of drug administration by mixing the medication with a carrier particle, such as microspheres, that controls the drug's release and absorption properties. Microspheres drug delivery, which is useful to improve the safety, efficacy, of the conventional dosage form and increase the patient compliance. This study designing it in form of mucoadhesive microspheres which prolong the residence time at the absorption site to facilitate intimate contact with absorption surface and thereby improve and enhance bioavailability. A well designed controlled drug delivery system can solve several issues with therapy. This mucoadhesion mechanism is based on various polymers, theories of mucoadhesion, suitable drug candidate. The mucoadhesive microspheres are prepared by various methods and its characterization which includes such as micromeritics properties, compatibility studies, particle size determination, percentage yield, drug entrapment efficiency, swelling index, mucoadhesive testing by in-vitro wash-off test, scanning electron microscopy, in-vitro drug release studies, and stability studies. The recent advances & Future challenges in microspheres manufacturing technology are arises that are beneficial to develop the novel approaches in drug delivery.

Keywords: Mucoadhesion, Entrapment efficiency, percentage yield, Swelling index, In-vitro drug release studies.