Abstract

THE EVOLUTION AND RECENT TRENDS OF TRANSDERMAL DRUG DELIVERY SYSTEM - A REVIEW

Chaitanya Gajanan Narwade*, Shivani Subhash Pangarekar and Tejeswini Vikramsingh Deshmukh

Abstract

To get around the challenges of oral medicine delivery, the transdermal drug delivery method was developed. A transdermal patch is an adhesive pharmaceutical patch applied to the skin that allows a prescribed dosage to enter the bloodstream through the skin. This frequently aids in the recovery of a damaged bodily part. The patch offers a controlled release of the medication into the patient, typically through a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. This is an advantage of a transdermal drug delivery route over other medication delivery methods like oral, topical, intravenous, intramuscular, etc. Some possible benefits of transdermal medication delivery include controlled absorption, more consistent plasma levels, enhanced bioavailability, fewer adverse effects, painless and easy application, and the ability to stop drug administration by simply removing the patch from the skin. Transdermal drug delivery (TDDS) is a promising technology that can reduce the need for needles for drug administration. However, the high cost of TDDS makes it a hidden part of therapy in developing nations such as India, where the population is the second highest.

Keywords: Transdermal, topical drug delivery, physicochemical evaluation, in vitro and in vivo drug release studies, Stability.