Abstract

A COMPARATIVE PHARMACEUTICO – ANALYTICAL AND EXPERIMENTAL STUDY OF PRATAPA MARTANDA RASA AND JWARAMURARI RASA W.S.R. TO ITS ANTIPYRETIC EFFECT

Purushottam K.*, Dinesh Kumar Mishra and Jagadeesha Mayya

Abstract

Pyrexia, also known as fever, is a common problem that impacts individuals of all ages, with the majority of people encountering it at least once in their life. It is an increase in body temperature resulting from an elevated set-point temperature caused by infections, inflammatory conditions, cancer, and specific drugs. If not managed, it can reach a level where it becomes a significant danger to life in many cases. Antipyretics act within the central nervous system to normalize a high temperature, therefore decreasing fever. Pyrexia is a prevalent problem tackled in every medical system through the global use of different antipyretic medications. Ayurveda, with a practice history of over 5,000 years, is one of the important ones. In Ayurveda, 'Jwara' is the term used to describe the same condition as a fever. There are many effective antipyretic drugs available in modern medicine, but they carry potential risks like side effects and drug resistance. Ayurveda provides various remedies for treating fever, but it is important to conduct experimental studies to determine the best and safest medicine. So here an attempt to take up the study for therapeutic comparative evaluation of Pratapa martanda Rasa and Jwaramurari Rasa for their Anti-pyretic effect”. Pharmaceutical study Preparation of Pratapa martanda Rasa and Jwaramurari Rasa Analytical study Both the formulations were analyzed physico-chemically, qualitatively and pH, Total solids, Total Ash, Ash value, Acid insoluble ash, Loss on drying, Water soluble extract, Alcohol soluble extract, Chemical Assay and other tests were marked out. Abstract “A COMPARATIVE PHARMACEUTICO – ANALYTICAL AND EXPERIMENTAL STUDY OF PRATAPA MARTANDA RASA AND JWARAMURARI RASA W.S.R. TO ITS ANTIPYRETIC EFFECT”. Experimental study: Wistar strain Albino rats were randomly selected and divided into 4 groups for the pyrexia induction using Brewer's yeast method. Grouping Rats Drug Control 6 Distilled water Standard drug 6 Paracetamol Suspension Trial drug-1 6 Pratapmartanda Rasa Trial drug-2 6 Jwaramurari Rasa Rectal temperature recorded at regular interval of 1 hour until for 18 hours. Results and discussion Both the Trial drugs showed significant anti-pyretic effect when compared with Control group. Both the Trial drugs exposed similar anti-pyretic effect when statistically compared with each other and Jwaramurari Rasa had better efficacy in controlling the temperature than Pratapmartanda Rasa.

Keywords: Jwara, Pyrexia, Antipyretic, Vati Kalpana, Pratapmartanda Rasa, Jwaramurari Rasa, Physico-chemical analysis, Brewers yeast.