Abstract

EXPLORING THE THERAPEUTIC POTENTIAL OF NATURAL PRODUCTS IN HEART FAILURE

Abhilasha Dara*, Yanna Sowjanya and Shaik Jakeer Hussain

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Abstract

Ventricular filling or blood ejection can be structurally or functionally impaired, leading to heart failure, a complex clinical condition. Fatigue, dyspnea, and fluid retention are the results of this. Heart failure may result from conditions affecting the myocardium, endocardium, pericardium, or heart valves. Severe hyperthyroidism and vitamin deficiencies are two more metabolic and nutritional disorders that can lead to heart failure. Daucus carota, Nerium oleander, Amaranthus Virdis, Ginkgo biloba, Terminalia arjuna, Picrorhiza kurroa, Salvia miltiorrhiza, Tinospora cordifolia, Mucuna pruriens, Hydrocotyle asiatica, Bombax ceiba, and Andrographis paniculate are a few well-known medicinal plants that are used to treat CVD. Flavonoids, polyphenols, plant sterol, plant sulphur compounds, and terpenoids are the active phytochemicals present in these plants. Preventing low-density lipoprotein oxidation, which encourages vasodilatation, is one way that flavonoids generally work. By reducing the blood's absorption of cholesterol, plant sterols can prevent CVD. By inhibiting the synthesis of cholesterol and activating nuclear factor-erythroid factor 2-related factor 2 (Nrf2), plant sulphur compounds also reduce CVD. Terpenoids reduce atherosclerotic lesions in the aortic valve, while quinone reduces the risk of CVD via boosting ATP generation in the mitochondria. Given the rising incidence of CVD, a number of physiologically active substances with established biological effects have been discovered in a variety of plants; nonetheless, suitable CVD prevention and treatment strategies are still needed. To fully comprehend the mechanism and phytochemicals found in particular plants that treat CVD,more research is required.

Keywords: Heart failure, Cardio vascular disease, ischemic heart disease .