Abstract

TO FORMULATE AND EVALUATE MULTIVITAMINS CONTAIN MICRO-EMULSION

Prerna Pardhi Rorokar*, Dr. Sheelpriya Walde and Dr. Kamlesh Wadher

Abstract

Multivitamin microemulsion is prepared by using various API’s like CO-Q10, Vit E, Vit. C, Oleic acid, Castor oil, Tween 80, Tween 20, Propylene glycol, Polyethylene Glycol 400 etc. with the help of all these API’s. Development of O/W microemulsion has been carried out by screening of components to find out excellent solubilisation and preservation for longer time. The preparation of O/W emulsion was carried out by phase- titration method. Characterization of microemulsion was done by simultaneous estimation of second order derivative spectra. The other evaluation parameters includes assay of Vit E, CO-Q10, Vit C, visual isotropy studies, viscosity, pH etc. The conclusion indicates on testing various parameters, the multivitamin microemulsion of CO-Q10, Vit E, Vit C offer an approved oral bioavaliabilty and enhance drug solubility, preservation, good and thermodynamically stability.

Keywords: Multivitamin microemulsion, O/W emulsion, Phase- titration method, approved oral bioavaliabilty.