Abstract

THERAPEUTIC POTENTIAL OF THESPESIA POPULNEA SEED EXTRACT IN THE TREATMENT OF ANDROGENETIC ALOPECIA: A PHYTOCHEMICAL AND PHARMACOLOGICAL PERSPECTIVE

Anjan Gowda B. H.*, Hemalatha K. V. and Gagana M. L.

Abstract

Thespesia populnea, a tree native in India’s coastal forest and tropical regions, which has demonstrated various therapeutic properties, like hepatoprotective, antibacterial, anti-inflammatory, and antioxidant effects. This study aims to further investigate the potential of T. populnea seed extract in treatment of alopecia, highlighting its rich chemical profile and possible applications in dermatological treatments. The present study explores the medicinal potential of Thespesia populnea (L.) seed, particularly in the treatment of androgenetic alopecia. Using the Soxhlet method of extraction, various bioactive compounds were extracted from the seeds. A wide variety of pharmacologically significant compounds, like B-sitosterol, thespone, thespesone, kaempferol, herbacetin, quercetin, and rutin. In particular B-sitosterol has shown to promote hair growth, making it a promising for treating hair loss conditions like alopecia. The results suggest that the active compounds in Thespesia populnea could provide a novel, plant-based approach to promote hair growth and treating alopecia.

Keywords: Thespesia populnea, Alopecia, Soxhlet extraction, B-sitosterol.