Abstract

THE ROLE OF ACTIVE PHARMACEUTICAL INGREDIENTS IN FORMULATION STRATEGIES FOR CHOLESTEROL-LOWERING MEDICATIONS

Dr. Payal N. Vaja*, Prof. Hiral S. Popaniya, Ms. Siddhi K. Upadhyay, Mr. Harsh H.

Abstract

Background: Cholesterol is a critical lipid required for various physiological functions, yet imbalances between high-density lipoprotein (HDL) and low-density lipoprotein (LDL) can lead to significant cardiovascular issues. Objective: This review aims to explore the role of active ingredients in the formulation strategies of cholesterol-lowering medications, focusing on their mechanisms of action, efficacy, and formulation considerations. Methods: A comprehensive literature review was conducted, analyzing various classes of anti- hyperlipidaemic drugs, including statins, bile acid sequestrants, and fibrates. The review highlights the chemical structures, pharmacological properties, and clinical implications of these active pharmaceutical ingredients (APIs). Discussions: The findings emphasize the importance of selecting appropriate active ingredients and formulation strategies to enhance drug efficacy, patient adherence, and overall treatment outcomes in managing hyperlipidaemia.

Keywords: Cholesterol, Anti-hyperlipidaemic drugs, Lipid management, Atorvastatin, Rosuvastatin.