Abstract

“A REVIEW ON TRANSFERSOMES IN ADVANCED DRUG DELIVERY SYSTEMS”

Omkar Chandrakant Renushe*, Dr. Abhishek Kumar Sen and Dr. Sonali Uppalwar

Abstract

A novel vesicular drug delivery method called transfersomes was created to improve medication penetration across biological membranes, especially the skin. Transdermal and targeted drug delivery have been transformed by these lipid-based, ultra-flexible, deformable carriers because they increase therapeutic efficacy, decrease systemic side effects, and improve bioavailability. The structure, composition, preparation techniques, mechanism of action, benefits, drawbacks, and most recent developments of transfersomebased drug delivery systems are all covered in detail in this review. Transdermal medication delivery devices are now much more effective thanks to recent developments in transfersome technology. Phospholipids and surfactants combine to form the specialized, elastic vesicles known as transfersomes, which help move medicinal substances over the epidermal barrier. This review focuses on the advancements in transfersome formulation, such as the incorporation of nanoparticles for better skin penetration, the use of penetration enhancers, and the adjustment of lipid composition. Important discoveries show that adding surfactants improves the permeability and flexibility of transfersomes, enabling the efficient administration of both hydrophilic and hydrophobic medications. Furthermore, new research suggests that iontophoresis and microneedles combined with transfersomes can increase drug delivery rates and bioavailability in general. Clinical uses of this technology have demonstrated promise in the treatment of long-term ailments such vaccine administration, hormone replacement therapy, and pain control. Transfersomes are a good choice for contemporary drug delivery systems because of their calability of manufacture and capacity to encapsulate a variety of pharmacological substances In conclusion, ongoing research into the mechanisms of skin absorption and the development of novel formulation strategies are expected to propel transfersome technology to the forefront of transdermal delivery solutions, offering improved patient compliance and therapeutic outcomes.

Keywords: Transfersomes, Advanced Drug Delivery Systems, Apllication.