Abstract

TRANSETHOSOMES: REVOLUTIONIZING TOPICAL AND TRANSDERMAL THERAPIES

Sudarshan D. J.*, J. Adlin Jino Nesalin, Ganesh N. S. and Vineeth Chandy

Abstract

Transdermal drug delivery has gained significant popularity in recent years as it addresses the limitations of oral administration. However, transporting drugs through the skin remains a challenge. To overcome this, researchers have developed systems where drugs are encapsulated in vesicles that can penetrate deeper into the skin to reach the target site, improving skin penetration of bioactive agents. While vesicular systems like liposomes, niosomes, ethosomes, and transferosomes typically accumulate in the skin layers, Transethosomes stand out due to their small particle size and ability to easily deform, allowing them to pass through the skin layers more effectively. Various methods are involved in the formulation of transethosomes such as hot method, cold method, reverse phase evaporation method, mechanical dispersion method. Due to deformable characteristics of vesicular system results in increased drug entrapment efficiency, permeation and penetration of drug into the deeper layer of skin. The characterization of the vesicles include morphology of transethosomes, particle size and zeta potential, entrapment efficiency, phase transition temperature, drug content, vesicle stability, skin permeation studies. These vesicular systems can be used for transdermal delivery of various drugs like antiviral, antihypertensive, anticancer, anti-arthritis etc.

Keywords: Transethosomes, Transdermal, Vesicular Delivery, Ultra deformable vesicles, Edge activators.