Abstract

FORMULATION AND EVALUATION VORICONAZOLE OINTMENT TO TREAT DERMATOPHYTOSIS

Poonam Ghule*, Anjali Neharkar, Priyanka Deshmukh, Prof. Sapna Ghuge and Dr. Kavita Kulkarni, Dr. Alim Shaikh

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Abstract

Voriconazole is a antifungal drug which Comes under the triazole group. Voriconazole is mainly used to treat encroaching or invasive fungal infection including aspergillosis, candidiasis, for the certain emerging fungal infections, penicilliosis and Coccidioidomycosis. The studies of voriconazole ointment were conducted with an aim to find or to develop out a desired ointment formulation for treatment of tungal infection like dermatophytosis (ring worms). The purpose of this study is to formulate the voriconazole ointment with different ointment bases having good diffusion, antiseptic & antifungal properties, & also the consistency. To assess the effecacy of formulation assay, viscosity, spreadability, Stability, permeability through the skil diffusion & other physical characteristics were can be evaluated. The formulation of the ointment was done by preparing the ointment base and incorporating the active ingredients in the accurate ratio into the base by fusion method to give the effective therapeutic action. PEG ointments were prepared with changing or altering the type of the liquid PEG (low molecular weight). Then, the Action of the voriconazole release from the formulation was studied.

Keywords: Voriconazole, ointment, PEG (polyethylene glycol), Antifungul action.