Abstract

IDENTIFICATION OF NOVEL TARGETS OF NEW INSULIN SENSITIZERS- STUDIES OF RELATED MECHANISM WITH OTHER GLUCOSE-LOWERING AGENTS

Mohammed H F Shalayel*, Moawia A Elbadri, Ihab Hamed Nourein, Ietimad AM Ayed, Mohammed Ayed Huneif

Abstract

Aims: To explains novel targets of currently used and new insulin sensitizers with emphasis on Sodium-glucose cotransporter-2 (SGLT- 2) inhibitors, G-protein-coupled receptors (GPCRs), thiazolidinediones, insulin secretogogues, and stem cell therapy. Method: Review of recent literature that emphasizes on novel targets and techniques belonging to glucose-lowering drugs and therapeutic intervention especially those studies that focus on new insulin sensitizers. Results and conclusion: Diabetes is a global major health problem that needs challenging and renewable medications every day as we need to individualize both treatment targets and treatment strategies. Identification of novel targets and techniques for therapeutic intervention will lead to more personalized approaches to treatment and hence to define which medication to be used in whom with regard to benefits and side effects.

Keywords: Sodium-glucose cotransporter-2 (SGLT-2) inhibitors; G-protein-coupled receptors (GPCRs); Metformin; Thiazolidinediones; Glucagon-like peptide-1 (GLP-1); Peroxisome proliferator-activated receptors (PPARs).